Approved for long-term use? Yes.
Side effects include abdominal cramping, passing gas, leaking oily stool, having more bowel movements, and not being able to control bowel movements.
These side effects are generally mild and temporary. But they may get worse if you eat high-fat foods.
Rare cases of severe liver injury have been reported in people taking orlistat, but it's not certain that the drug caused those problems.
What else you should know: You should be on a low-fat diet (less than 30% of your daily calories from fat) before taking orlistat.
Also, take a multivitamin at least 2 hours before or after
taking xenical, because the drug temporarily makes it harder for your
body to absorb vitamins A, D, E, and K.
Xenical is the only drug of its kind that's approved in the
U.S. All other prescription weight loss drugs curb your appetite,
including the following.